Author

S. Vasiljevic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

M. Hensen· 4 shared N. Zitzmann· 4 shared A. V. Chandran· 3 shared A. Lia· 2 shared A. Santino· 2 shared C. P. Modenutti· 2 shared D. S. Alonzi· 2 shared J. Brun· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersBiochemistry

M. Hensen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cooperativity and induced oligomerisation control the interaction of SARS- CoV-2 with its cellular receptor and patient-derived antibodies

R. Asor, A. Olerinyova, S. A. Burnap, M. S. Kushwah, F. Soltermann, L. P. Rudden, M. Hensen, S. Vasiljevic, J. Brun, M. Hill, L. Chang, W. Dejnirattisai, P. Supasa, J. Mongkolsapaya, D. Zhou, , P. Kukura

The paper investigates how multivalent interactions between SARS-CoV-2 spike protein, ACE2 receptor, and patient-derived antibodies influence viral entry and antibody inhibition.

bioRxiv · Sep 14, 2023 · PreprintBiophysics

A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint

K. P. Guay, R. Ibba, J. L. Kiappes, M. De Benedictis, I. Zeni, J. D. Le Cornu, M. Hensen, A. V. Chandran, A. L. Kantsadi, A. T. Caputo, J. I. Blanco Capurro, Y. Bayo, J. C. Hill, K. Hudson, A. Lia, , P. Roversi

This paper identifies a small molecule inhibitor of UGGT, a key enzyme in ER glycoprotein folding, and demonstrates its inhibitory effects in vitro and in cell culture.

bioRxiv · Jun 21, 2022Biochemistry

Analysis of SARS-CoV-2 spike glycosylation reveals shedding of a vaccine candidate

J. Brun, S. Vasiljevic, B. Gangadharan, M. Hensen, A. V. Chandran, M. L. Hill, J. L. Kiappes, R. A. Dwek, D. S. Alonzi, W. B. Struwe, N. Zitzmann

The paper compares glycosylation patterns between SARS-CoV-2 viral spikes and a vaccine candidate, showing differences in secretion pathways and potential implications for immune response and vaccine design.

bioRxiv · Nov 16, 2020 · PreprintBiochemistry

Networks of HIV-1 envelope glycans maintain antibody epitopes in the face of glycan additions and deletions

G. E. Seabright, C. A. Cottrell, M. J. van Gils, A. D'addabbo, D. J. Harvey, A.-J. Beherns, J. D. Allen, Y. Watanabe, A. Maker, S. Vasiljevic, N. de Val, R. W. Sanders, A. B. Ward, M. Crispin

The paper investigates how HIV-1 envelope glycan networks affect the formation and stability of broadly neutralizing antibody epitopes, showing their importance in immunogen design.

bioRxiv · Feb 21, 2020Immunology

Clamping, bending, and twisting inter-domain motions in the misfold-recognising portion of UDP glucose:glycoprotein glucosyl-transferase.

C. P. Modenutti, J. I. Blanco Capurro, R. Ibba, S. Vasiljevic, M. Hensen, D. S. Alonzi, A. V. Chandran, J. C. Hill, J. Rushton, A. Kumar, S. Rubichi, A. Lia, G. Tax, L. Marti, A. Santino, , P. Roversi

This study uses molecular dynamics simulations and structural analysis to characterize inter-domain motions in UGGT, revealing conformational flexibility and a proposed Parodi limit for substrate recognition.

bioRxiv · Dec 25, 2019Biochemistry