J. M. Kahlenberg

Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity

The paper identifies ZBP1 and mitochondrial Z-DNA as drivers of autoimmune photosensitivity through cGAS-STING activation in response to UVB.

Type I interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection

This paper shows type I interferon coordinates immunometabolic checkpoints during Staphylococcal infection by regulating metabolic and inflammatory programs in macrophages.

Nuclear proteins acquiring Germinal Center B cells are specifically suppressed by follicular regulatory T cells.

The paper shows that follicular regulatory T cells (Tfrs) suppress GC B cells acquiring nuclear proteins, indicating direct Tfr-GC B cell interactions regulate effector B cell responses.

The lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope

This study identifies a DRB1*03:01-encoded epitope that drives a lupus-like transcriptome and cellular aberrations in macrophages, revealing a noncanonical mechanism of HLA-disease association in SLE.

Single cell transcriptomics reveals distinct effector profiles of infiltrating T cells in lupus skin and kidney

This study uses single-cell RNA sequencing to analyze T and NK cells in cutaneous lupus skin and kidney, revealing distinct effector profiles and activation states across tissues.

Non-lesional and Lesional Lupus Skin Share Inflammatory Phenotypes that Drive Activation of CD16+ Dendritic Cells

The paper compares non-lesional and lesional lupus skin to show they share inflammatory features that activate CD16+ dendritic cells.