MSCs from syndecan-3 null mice exhibit enhanced adhesion to collagen type I, hyperactivation of the AKT pathway and increased efficacy in inflammatory arthritis
F. K. Jones, A. Stefan, A. G. Kay, M. Hyland, R. Morgan, N. R. Forsyth, A. Pisconti, O. Kehoe
This study shows that SDC3-deficient MSCs adhere better to collagen I, have hyperactive AKT signaling, and are more effective in treating inflammatory arthritis.
bioRxiv · Jun 12, 2020Immunology