Author

N. R. Forsyth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. G. Kay· 2 shared M. Hyland· 2 shared O. Kehoe· 2 shared R. Morgan· 2 shared T. P. Dale· 2 shared A. Piccinini· 1 shared A. Pisconti· 1 shared A. Stefan· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

A. G. Kay

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Decellularisation and characterisation of porcine pleura for lung tissue engineering

T. Vikranth, T. P. Dale, N. R. Forsyth

This paper develops a decellularisation protocol for porcine pleura, demonstrating effective removal of cellularity while preserving ECM structure and mechanical properties suitable for lung tissue engineering.

bioRxiv · Jun 20, 2023 · PreprintBioengineering

Hypoxic conditions promote a proliferative, poorly differentiated, and pro-secretory phenotype in COPD lung tissue progenitor cells in vitro

T. P. Dale, M. D. Santer, M. Haris, W. Zuo, N. R. Forsyth

This study shows hypoxia increases proliferation and secretory phenotype in COPD lung progenitor cells while reducing differentiation capacity.

bioRxiv · Mar 22, 2022Physiology

Physoxia influences global and gene-specific methylation in pluripotent stem cells

F. Dogan, R. M. K. Al Jumaily, M. Kitchen, N. R. Forsyth

This study shows that low oxygen (physoxia) culture alters DNA methylation and expression of methylating enzymes in pluripotent stem cells.

bioRxiv · Mar 21, 2022Cell Biology

THERAPEUTIC EFFECTS OF HYPOXIC AND PRO-INFLAMMATORY PRIMING OF MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES IN INFLAMMATORY ARTHRITIS

A. G. Kay, K. Treadwell, P. Roach, R. Morgan, R. Lodge, M. Hyland, A. Piccinini, N. R. Forsyth, O. Kehoe

This study evaluates the therapeutic effects of hypoxically and pro-inflammatory primed MSC-derived EVs in inflammatory arthritis, finding normoxic EVs most effective in reducing joint swelling and improving histopathology.

bioRxiv · Jun 28, 2021Immunology

MSCs from syndecan-3 null mice exhibit enhanced adhesion to collagen type I, hyperactivation of the AKT pathway and increased efficacy in inflammatory arthritis

F. K. Jones, A. Stefan, A. G. Kay, M. Hyland, R. Morgan, N. R. Forsyth, A. Pisconti, O. Kehoe

This study shows that SDC3-deficient MSCs adhere better to collagen I, have hyperactive AKT signaling, and are more effective in treating inflammatory arthritis.

bioRxiv · Jun 12, 2020Immunology