Author

A. G. Kay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

M. Hyland· 2 shared N. R. Forsyth· 2 shared O. Kehoe· 2 shared R. Morgan· 2 shared A. L. Barnes· 1 shared A. P. Stone· 1 shared A. Piccinini· 1 shared A. Pisconti· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

M. Hyland

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Extracellular matrices of bone marrow stroma regulate cell phenotype and contribute to distinct stromal niches in vivo

A. P. Stone, E. Rand, G. Thornes, A. G. Kay, A. L. Barnes, I. S. Hitchcock, P. Genever

This study shows that extracellular matrix (ECM) from stem-like bone marrow stromal cells enhances migration in non-stem cells and is enriched in proteins like aggrecan and periostin, which are associated with stromal niches in bone.

bioRxiv · Jan 19, 2023 · PreprintCell Biology

Identification of CD317-Positive Pro-inflammatory Immune Stromal Cells in Human Mesenchymal Stromal Cell Preparations

A. G. Kay, J. M. Fox, J. Hewitson, A. Stone, S. Robertson, S. R. James, X.-N. Wang, E. Kapasa, X. B. Yang, P. G. Genever

The paper identifies CD317-positive pro-inflammatory immune stromal cells in human MSC preparations and shows their distinct functional roles in inflammation and immunomodulation.

bioRxiv · Feb 10, 2022 · PreprintCell Biology

THERAPEUTIC EFFECTS OF HYPOXIC AND PRO-INFLAMMATORY PRIMING OF MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES IN INFLAMMATORY ARTHRITIS

A. G. Kay, K. Treadwell, P. Roach, R. Morgan, R. Lodge, M. Hyland, A. Piccinini, N. R. Forsyth, O. Kehoe

This study evaluates the therapeutic effects of hypoxically and pro-inflammatory primed MSC-derived EVs in inflammatory arthritis, finding normoxic EVs most effective in reducing joint swelling and improving histopathology.

bioRxiv · Jun 28, 2021Immunology

MSCs from syndecan-3 null mice exhibit enhanced adhesion to collagen type I, hyperactivation of the AKT pathway and increased efficacy in inflammatory arthritis

F. K. Jones, A. Stefan, A. G. Kay, M. Hyland, R. Morgan, N. R. Forsyth, A. Pisconti, O. Kehoe

This study shows that SDC3-deficient MSCs adhere better to collagen I, have hyperactive AKT signaling, and are more effective in treating inflammatory arthritis.

bioRxiv · Jun 12, 2020Immunology