Author

G. Muruganandam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:protein folding & dynamics· 3 Assay:structural biology· 3 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1

Frequent Co-Authors

R. Loris· 6 shared P. Kursula· 5 shared A. Raasakka· 4 shared A. Martinez· 2 shared A. Sutinen· 2 shared E. I. Hallin· 2 shared G. T. T. Nguyen· 2 shared H. J. Bustad· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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6 shared papersBiochemistry

R. Loris

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Author profile →

6 papers

Recent·Most cited

Structural insights into Charcot-Marie-Tooth disease-linked mutations in human GDAP1

A. Sutinen, G. T. T. Nguyen, A. Raasakka, G. Muruganandam, R. Loris, E. Ylikallio, H. Tyynismaa, L. Bartesaghi, S. Ruskamo, P. Kursula

This study investigates the structural and biochemical effects of CMT-linked GDAP1 mutations, finding reduced thermal stability and disrupted interaction networks that may impair neuronal function.

bioRxiv · Feb 18, 2022Biochemistry

High-affinity nanobodies as tools for structural and functional studies on mammalian Arc

S. Markusson, E. I. Hallin, H. J. Bustad, A. Raasakka, J. Xu, G. Muruganandam, R. Loris, A. Martinez, C. Bramham, P. Kursula

This study produces and characterizes high-affinity anti-Arc nanobodies, revealing structural dynamics of Arc CTD and its role in oligomerization and capsid formation.

bioRxiv · Dec 16, 2021 · PreprintBiochemistry

Entropic pressure controls oligomerization of Vibrio cholerae ParD2 antitoxin

G. Garcia-Rodriguez, Y. A. Girardin, A. N. Volkov, R. K. Singh, G. Muruganandam, J. Van Dyck, F. Sobott, W. Versées, R. Loris

This study shows that the intrinsically disordered C-terminal domain of VcParD2 restricts its oligomerization to stable 10-mer or 12-mer structures due to entropic pressure.

bioRxiv · Mar 9, 2021Biophysics

Structure of the complete dimeric human GDAP1 core domain provides insights into ligand binding and clustering of disease mutations

G. T. T. Nguyen, A. Sutinen, A. Raasakka, G. Muruganandam, R. Loris, P. Kursula

The paper determines the crystal structure of the human GDAP1 core domain, identifies a fatty acid ligand, and reveals structural insights into disease-related mutations and oligomerization.

bioRxiv · Nov 13, 2020Biochemistry

Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase

E. Mahootchi, A. Raasakka, W. Luan, G. Muruganandam, R. Loris, J. Haavik, P. Kursula

The paper determines the crystal structure of mouse CSAD, identifies substrate specificity determinants, and shows open/close motions in solution.

bioRxiv · Sep 25, 2020Biochemistry

Molecular determinants of Arc oligomerization and formation of virus-like capsids

M. S. Eriksen, O. Nikolaienko, E. I. Hallin, S. Grodem, H. J. Bustad, M. I. Flydal, R. O'Connell, T. Hosokawa, D. Lascu, S. Akerkar, J. Cuellar, J. J. Chambers, I. Merski, G. Muruganandam, R. Loris, , C. R. Bramham

This paper identifies a 28-amino-acid region in Arc critical for oligomerization and virus-like capsid formation, showing that exogenous RNA enhances assembly.

bioRxiv · Nov 22, 2019 · PreprintBiochemistry