Author

A. T. Ayoub

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Savarino· 1 shared B. Lucic· 1 shared C. J. Neufeldt· 1 shared D. Havelka· 1 shared F. Apollonio· 1 shared I. L. Shytaj· 1 shared J. A. Tuszynski· 1 shared J. Prusa· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperMicrobiology

A. Savarino

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

The FDA-approved drug cobicistat synergizes with remdesivir to inhibit SARS-CoV-2 replication

I. L. Shytaj, M. Fares, B. Lucic, L. Gallucci, M. M. Tolba, L. Zimmermann, A. T. Ayoub, M. Cortese, C. J. Neufeldt, V. Laketa, P. Chlanda, O. T. Fackler, S. Boulant, R. Bartenschlager, M. Stanifer, , M. Lusic

This study shows that cobicistat synergizes with remdesivir to inhibit SARS-CoV-2 replication in cell lines and organoids, reducing viral replication to levels comparable to uninfected cells.

bioRxiv · Mar 9, 2021Microbiology

Tubulin as a sensitive target of nanosecond-scale intense electric field: quantitative insights from molecular dynamics simulations

P. Marracino, D. Havelka, J. Prusa, M. Liberti, J. A. Tuszynski, A. T. Ayoub, F. Apollonio, M. Cifra

This study uses molecular dynamics simulations to show that intense nanosecond electric fields can alter β-tubulin conformations and drug binding sites, suggesting potential for modulating microtubule dynamics.

bioRxiv · Jan 29, 2019 · PreprintBiophysics