Molecular mechanism for strengthening E-cadherin adhesion using a monoclonal antibody
B. Xie, A. Maker, A. V. Priest, D. M. Dranow, J. N. Phan, T. E. Edwards, B. Staker, P. J. Myler, B. M. Gumbiner, S. Sivasankar
This study identifies how the monoclonal antibody 19A11 strengthens E-cadherin adhesion through a salt bridge that stabilizes the strand-swap dimer interface.
bioRxiv · Mar 6, 2022Biophysics