S. Yamada

An in vivo platform to identify pathogenic loci

This study uses Drosophila tissue-specific gene knockdown to assess the functional impact of seven conserved disease genes, showing their effects on viability, behavior, and neuronal survival.

Phase transition of tensin-1 during the focal adhesion disassembly and cell division

This study shows that tensin-1 forms biomolecular condensates during focal adhesion disassembly and cell division, with cell cycle-dependent dynamics and specific protein composition.

Impact of reinfection with SARS-CoV-2 Omicron variants in previously infected hamsters

This study investigates reinfection with SARS-CoV-2 Omicron variants in previously infected hamsters, finding that immunity prevents pneumonia but allows viral replication in the upper airways with increased mutation diversity.

Diagnosis and early prediction of lymphoma using high-throughput clonality analysis of bovine leukemia virus-infected cells

This study evaluates RAISING-CLOVA's ability to detect clonality in BLV-infected cells, showing high sensitivity and specificity in distinguishing EBL from non-EBL cattle and confirming its utility for early detection.

Uncertainty quantification in cerebral circulation simulations focusing on the collateral flow: Surrogate model approach with machine learning

This paper develops a machine learning surrogate model to rapidly quantify uncertainty in cerebral circulation simulations, enabling real-time risk assessment of cerebral hyperperfusion after carotid artery stenosis surgery.

Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.2

The paper compares the efficacy of neutralizing antibodies and antiviral drugs against SARS-CoV-2 Omicron subvariants BA.1 and BA.2, finding differential responses to specific treatments.

Cell Adhesion-Dependent Biphasic Axon Outgrowth Elucidated by Femtosecond Laser Impulse

This study uses femtosecond laser impulses to investigate how adhesion strength affects axon outgrowth, finding biphasic behavior due to the balance between traction force and adhesion strength.

Guided Axon Outgrowth of Neurons by Real-Time Femtosecond Laser Penetration on a 4 μm Thick Thin-Glass Sheet

This study uses a real-time femtosecond laser and microfluidic device to guide axon outgrowth by creating netrin-1 gradients, achieving 92% guided axon growth.

A Ca2+ wave generates a force during cell extrusion in zebrafish

This study shows that a Ca2+ wave in zebrafish generates force during cell extrusion by inducing polarized movements via IP3 receptor and trpc1.

Clomipramine suppresses ACE2-mediated SARS-CoV-2 entry

This study shows clomipramine inhibits SARS-CoV-2 entry into cardiomyocytes and synergizes with remdesivir to suppress infection.

Optimization of an LNP-mRNA vaccine candidate targeting SARS-CoV-2 receptor-binding domain

This study optimizes an LNP-mRNA vaccine targeting SARS-CoV-2 RBD by removing reactogenic materials, improving immunogenicity and protection in macaques.

A highly attenuated vaccinia virus strain LC16m8-based vaccine for severe fever with thrombocytopenia syndrome

This paper develops and tests recombinant vaccinia virus vaccines against SFTS, showing they induce protective immunity and are safe in mice.

Mapping transmembrane binding partners for E-cadherin ectodomains.

The paper identifies novel transmembrane protein interactions of E-cadherin ectodomains using proximity labeling and single molecule binding assays.

Condensation of pericentrin proteins in human cells illuminates phase separation in centrosome assembly

The paper shows pericentrin proteins condense into dynamic granules during mitosis, facilitating centrosome maturation through phase separation.

Inside-out regulation of E-cadherin conformation and adhesion

This study shows vinculin regulates cadherin conformation and adhesion by converting weak X-dimers to strong strand-swap dimers through myosin II-dependent cytoskeletal tension changes.

CDK1 dependent phosphorylation of hTERT contributes to cancer progression

The paper shows CDK1 phosphorylates hTERT at threonine 249, which is required for RdRP activity and promotes cancer progression independently of telomerase.