Author

P. T. Nguyen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

V. Yarov-Yarovoy· 4 shared J. T. Sack· 2 shared A. Ghetti· 1 shared A. L. Wang· 1 shared A. R. Patwardhan· 1 shared A. T. Ton· 1 shared A. V. Molofsky· 1 shared A. Viale· 1 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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4 shared papersBiophysics

V. Yarov-Yarovoy

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

KRAS inhibition activates an actionable CD24 do-not-eat-me signal in pancreatic cancer

Y. Wei, M. Liu, E.-Y. Yen, J. Yao, Z. Xun, P. T. Nguyen, X. Wang, Z. Yang, A. Yousef, D. Pan, Y. Jin, C.-F. Li, M. S. Theardy, J. Park, Y. Cai, , H. Ying

This study identifies CD24 as an actionable signal activated by KRASG12C inhibition in pancreatic cancer, enhancing macrophage phagocytosis and sensitizing tumors to therapy.

bioRxiv · Sep 21, 2023Cancer Biology

Electron transport inhibition increases cellular dependence on purine transport and salvage

Z. Wu, D. Bezwada, R. C. Harris, C. Pan, P. T. Nguyen, B. Faubert, L. Cai, F. Cai, H. S. Vu, H. Chen, M. Martin-Sandoval, D. Do, W. Gu, Y. Zhang, B. Ko, , R. J. DeBerardinis

This study shows that ETC inhibition in cancer cells increases reliance on purine salvage and transport, revealing a metabolic vulnerability in tumors with low oxidative metabolism.

bioRxiv · May 11, 2023Biochemistry

Molecular Determinants of μ-Conotoxin KIIIA interaction with the Voltage-Gated Sodium Channel Nav1.7

I. H. Kimball, P. T. Nguyen, B. M. Olivera, J. T. Sack, V. Yarov-Yarovoy

The paper identifies molecular interactions between μ-conotoxin KIIIA and hNaV1.7 using computational modeling, experimental validation, and structural analysis.

bioRxiv · Feb 2, 2023 · PreprintBiophysics

TRPV1 Opening is Stabilized Equally by Its Four Subunits

S. Li, P. T. Nguyen, S. Vu, V. Yarov-Yarovoy, J. Zheng

The paper measures how RTX binding to TRPV1 subunits affects channel opening, finding each subunit contributes equally to activation energy.

bioRxiv · Jan 26, 2023 · PreprintBiophysics

Computational design of peptides to target Nav1.7 channel with high potency and selectivity for the treatment of pain

P. T. Nguyen, H. M. Nguyen, K. M. Wagner, R. Stewart, V. Singh, P. Thapa, Y.-J. Chen, M. W. Lillya, A. T. Ton, R. Kondo, A. Ghetti, M. W. Pennington, B. Hammock, T. N. Griffith, J. T. Sack, , V. Yarov-Yarovoy

The paper designs potent and selective peptide inhibitors of human NaV1.7 channels using Rosetta, with two peptides showing sub-nanomolar IC50 and high selectivity over other sodium channels.

bioRxiv · Jul 21, 2022Biophysics

The Influences of Stomatal Size and Density on Rice Drought, Salinity and VPD Resilience

R. S. Caine, E. L. Harrison, J. M. Sloan, P. M. Flis, S. Fischer, T. L. Nguyen, P. T. Nguyen, J. E. Gray, H. L. Croft

The paper examines how stomatal size and density in rice affect resilience to drought, salinity, and VPD, finding that traditional varieties with high density and small size are more drought-resistant than those with low density and large size.

bioRxiv · May 13, 2022Plant Biology

A genetically encoded, pH-sensitive mTFP1 biosensor for probing lysosomal pH

M. Y. Chin, A. R. Patwardhan, K.-H. Ang, A. L. Wang, C. Alquezar, M. Welch, P. T. Nguyen, M. Grabe, A. V. Molofsky, M. R. Arkin, A. W. Kao

The paper develops a genetically encoded pH biosensor, FIRE-pHLy, for lysosomal pH measurement and demonstrates its use in cellular models.

bioRxiv · Nov 4, 2020 · PreprintCell Biology

A Molecular Taxonomy of Tumors Independent of Tissue-of-Origin

P. T. Nguyen, S. G. Coetzee, D. L. Lakeland, D. J. Hazelett

This paper identifies ten molecular tumor clusters independent of tissue-of-origin, showing that common driver genes and tissue-specific pathway disruptions create distinct molecular phenotypes.

bioRxiv · Aug 26, 2020Cancer Biology

Structural Basis for Antiarrhythmic Drug Interactions with the Human Cardiac Sodium Channel

P. T. Nguyen, K. R. DeMarco, I. Vorobyov, C. E. Clancy, V. Yarov-Yarovoy

This study investigates the molecular interactions of antiarrhythmic and local anesthetic drugs with hNav1.5 using structural modeling and simulations, revealing key binding sites and pathways.

bioRxiv · Sep 29, 2018Biophysics