Author

A. Wlodawer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 3 Assay:protein structure· 3 Research Focus:host-pathogen & immune response· 2 Organism:plant (other)· 1 Organism:rat· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Deshmukh· 2 shared A. Gustchina· 2 shared H. Iwai· 2 shared H. M. Beyer· 2 shared I. Rathore· 2 shared K. M. Mikula· 2 shared P. Bhaumik· 2 shared R. Y. Yada· 2 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

A. Deshmukh

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Molecular insights into the inhibition of plasmepsins by HIV-1 protease inhibitors: Implications for antimalarial drug discovery

V. Mishra, I. Rathore, A. Deshmukh, S. Patankar, A. Gustchina, A. Wlodawer, R. Y. Yada, P. Bhaumik

This study investigates how HIV-1 protease inhibitors inhibit plasmepsins in Plasmodium falciparum, revealing structural insights that could guide the development of new antimalarial drugs.

bioRxiv · Sep 27, 2021 · PreprintBiochemistry

Structures of plasmepsin X from P. falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme

p. kesari, A. Deshmukh, N. Pahelkar, A. B. Suryawanshi, I. Rathore, V. Mishra, J. H. Dupuis, H. Xiao, A. Gustchina, J. Abendroth, M. Labaied, R. Y. Yada, A. Wlodawer, T. E. Edwards, D. D. Lorimer, P. Bhaumik

The paper reports the crystal structure of PfPMX zymogen, revealing a novel inactivation mechanism and molecular basis for inhibitor binding in the mature enzyme.

bioRxiv · Sep 24, 2021Biophysics

Control of SARS-CoV-2 infection after Spike DNA or Spike DNA+Proteinco-immunization in rhesus macaques

M. Rosati, M. Agarwal, X. Hu, S. Devasundaram, D. Stellas, B. Chowdhury, J. Bear, R. Burns, D. Donohue, L. Pessaint, H. Andersen, M. G. Lewis, E. Terpos, M. A. Dimopoulos, A. Wlodawer, , B. K. Felber

This study compares DNA and DNA+protein vaccines in rhesus macaques, finding that co-immunization with both induces stronger antibody responses and better control of SARS-CoV-2 infection.

PLOS Pathogens · Sep 22, 2021Peer-reviewedImmunology

Convergent evolution of the Hedgehog/Intein fold in protein splicing

H. M. Beyer, S. I. Virtanen, A. S. Aranko, K. M. Mikula, G. T. Lountos, A. Wlodawer, O. H. S. Ollila, H. Iwai

The paper investigates the structural basis of protein splicing in class 3 inteins and proposes the HINT fold as an example of convergent evolution of an entire protein fold.

bioRxiv · Mar 19, 2020Biochemistry

The crystal structure of the naturally split gp41-1 intein guides the engineering of orthogonal split inteins from a cis-splicing intein

H. M. Beyer, K. M. Mikula, M. Li, A. Wlodawer, H. Iwai

The paper determines the crystal structure of a split gp41-1 intein and uses it to engineer orthogonal split inteins from a cis-splicing intein.

bioRxiv · Feb 11, 2019Biochemistry