P. Bhaumik

Conformational dynamics associated with remote residues regulate the kinetic properties of homologous glutamate dehydrogenases (GDHs)

This study identifies remotely located residues and conformational dynamics as regulators of kinetic properties in homologous glutamate dehydrogenases.

Inter-subunit Crosstalk via PDZ Synergistically Governs Allosteric Activation of Proapoptotic HtrA2

This study investigates how PDZ domains in HtrA2 subunits synergistically regulate allosteric activation through inter-subunit crosstalk, revealing a model of cooperative energy landscape dynamics.

Molecular insights into the inhibition of glutamate dehydrogenase (GDH) by the dicarboxylic acid metabolites

This study investigates how dicarboxylic acid metabolites inhibit Aspergillus terreus GDH by analyzing crystal structures and binding interactions.

Molecular insights into the inhibition of plasmepsins by HIV-1 protease inhibitors: Implications for antimalarial drug discovery

This study investigates how HIV-1 protease inhibitors inhibit plasmepsins in Plasmodium falciparum, revealing structural insights that could guide the development of new antimalarial drugs.

Structures of plasmepsin X from P. falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme

The paper reports the crystal structure of PfPMX zymogen, revealing a novel inactivation mechanism and molecular basis for inhibitor binding in the mature enzyme.

Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle

This paper identifies structural changes in a non-hemolytic pneumolysin variant that disable pore formation, enabling pneumococcus to adopt an intracellular lifestyle with reduced inflammation and increased host tolerance.