K. S. Campbell

Reduction in activity and abundance of mitochondrial electron transport chain supercomplexes in pulmonary hypertension-induced right ventricular dysfunction

This study shows reduced mitochondrial supercomplex activity and abundance in pulmonary hypertension-induced right ventricular dysfunction in rats and humans.

Unfolded Von Willebrand Factor Binds Protein S and Reduces Anticoagulant Activity

This paper identifies a shear-dependent interaction between Protein S and von Willebrand Factor that reduces free PS anticoagulant activity and contributes to thrombotic risk in viral infections.

History-dependent muscle resistance to stretch remains high after small, posturally-relevant pre-movements

The study examines how muscle resistance to stretch is affected by prior movement history, finding that small, slow pre-movements preserve resistance, while larger, faster movements reduce it.

zDHHC5 expression is increased in cardiac hypertrophy and reduced in heart failure but this does not correlate with changes in substrate palmitoylation

This study examines zDHHC5 expression and palmitoylation changes in cardiac diseases, finding increased zDHHC5 in hypertrophy and decreased in failure, with no correlation to substrate palmitoylation changes.

FiberSim: a flexible open-source model of myofilament-level contraction

FiberSim simulates myofilament-level contraction mechanics and demonstrates how sarcomeric protein modulation affects contractility.

IL-27R signaling serves as immunological checkpoint for NK cells to promote hepatocellular carcinoma

This study identifies IL-27R signaling as an immunological checkpoint that suppresses NK cell activity, thereby promoting hepatocellular carcinoma development across different etiologies.

Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super-relaxed state: multiscale measurements and computational modeling

This study investigates the P710R mutation in β-cardiac myosin, showing it causes hypercontractility by disrupting the super-relaxed state, using multiscale experiments and modeling.

Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells

This study shows MEK inhibitors reduce ACE2 and inflammatory cytokines, enhance NK cell activity, and block SARS-CoV-2 pseudovirus infection in human cells.

Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblastdriven nutritional support and immunosuppression

This study identifies Netrin G1 as a promoter of pancreatic ductal adenocarcinoma tumorigenesis by enhancing cancer-associated fibroblast-driven metabolic support and immunosuppression.