U. Alon

Unifying design principles of endocrine gland mass and its regulatory circuits

This study identifies unifying design principles of endocrine gland mass and regulatory circuits across human hormone systems using mathematical analysis.

Pregnancy and postpartum dynamics revealed by millions of lab tests

This study analyzes 76 lab tests across 300,000 pregnancies to reveal physiological dynamics during pregnancy and postpartum, showing delayed return to baseline and distinct patterns for complications.

p16-dependent upregulation of PD-L1 impairs immunosurveillance of senescent cells

This study identifies p16-dependent upregulation of PD-L1 in senescent cells as a mechanism to evade immune clearance, showing that anti-PD-L1 treatment can eliminate these cells.

A cell circuit approach to dissect fibroblast-macrophage interactions in the tumor microenvironment

The paper uses a cell circuit approach to analyze fibroblast-macrophage interactions in the tumor microenvironment, finding that fibroblasts rely on autocrine growth factors while macrophages depend on external cues.

Cancer-associated fibroblast compositions change with breast cancer progression linking S100A4 and PDPN ratios with clinical outcome

The paper tracks changes in cancer-associated fibroblast (CAF) subpopulations during breast cancer progression, linking their ratios to clinical outcomes and BRCA mutations.

A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks

This paper develops a new mathematical model of the HPA axis that explains dysregulation of stress hormones over weeks by incorporating gland mass dynamics and growth factor effects.

Endocrine autoimmune disease as a fragility of immune-surveillance against hypersecreting mutants

This paper proposes a theory that endocrine autoimmune diseases arise from a fragility in immune surveillance against hypersecreting mutant cells.

Tradeoffs and cultural diversity

The paper applies Pareto task inference to cultural trait data, identifying tradeoffs between three tasks in Austronesian and hunter-gatherer cultures.

Identity domains in complex behavior: Toward a biology of personality

The paper introduces a mathematical framework to study individual differences in behavior and gene expression in mice, validated using high-throughput behavioral data.