Sevinç Ercan

This study shows TFIIIC regulates SMC complex binding and 3D DNA contacts between tRNA genes independently of RNA Pol III.

The paper identifies a developmental timer in C. elegans that coordinates microRNA transcription across tissues through a feedback loop between MYRF-1 and LIN-42.

The paper identifies MYRF-1 as a regulator of non-apoptotic linker cell death in C. elegans, showing its role in priming death through activation of pqn-41/polyQ.

This study shows that X chromosome dosage compensation mechanisms evolved independently in two nematode lineages through parallel evolution of SMC complexes.

This study identifies DMD-3 target genes and regulatory mechanisms involved in C. elegans male tail tip morphogenesis using ChIP-seq and functional analysis.

This study investigates cohesin's role in organizing 3D DNA contacts around active enhancers in C. elegans, revealing cohesin-dependent 'fountains' and differences in processivity compared to mammals.

This study shows DNA supercoiling affects transcription initiation and elongation in C. elegans, with directional impacts on gene expression based on genomic context.

The paper develops a smFISH method with computational staging to study transcription dynamics in C. elegans embryos and finds that the DCC reduces dpy-23 transcription frequency.

This study shows that topoisomerases I and II regulate condensin DC translocation on the X chromosome in C. elegans, with TOP-2 affecting long-range movement and TOP-1 affecting short-range movement, both essential for gene repression.

The paper shows that condensin DC spreads from rex sites to form TADs on the X-chromosome in C. elegans, but not on autosomes unless rex sites are artificially added.

The paper shows that increased gene dosage in C. elegans leads to increased mRNA expression, indicating no genome-wide dosage compensation mechanism at the mRNA level.

The paper predicts enhancer activity in sea urchin embryos using chromatin accessibility, transcription, and Pol II data, finding Pol II distribution is the best predictor for promoter-overlapping elements.

The paper introduces an engineered auxin analog and AtTIR1(F79G) pair to improve the specificity and efficacy of the auxin degradation system in C. elegans.

The paper identifies an epigenetic priming mechanism mediated by BLMP-1 that decompacts chromatin to regulate transcriptional output in response to nutrient sensing.

The paper shows that DCC binding reduces active histone modifications at X chromosome gene regulatory elements, fine-tuning X transcription.

This study shows that acute condensin depletion in yeast causes genome decompaction without affecting global gene expression levels.