Author

Abdelkader Essafi

Great Ormond Street Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alex von KriegsheimiD· 1 shared Alexander L. R. LubbockiD· 1 shared Andrew H. SimsiD· 1 shared Bret S.E. HealeiD· 1 shared Debasis Mohapatra· 1 shared Erola Pairo‐CastineiraiD· 1 shared Giulia Petrovich· 1 shared Ian M. OvertoniD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Alex von KriegsheimORCID

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2 papers

Recent·Most cited

Tumour suppressor WT1 and its interacting protein RNA helicase DDX5 regulate the microRNA let7/Igf1r axis in the kidney mesenchyme

Sourav Dey, Joan Slight, Stuart Aitken, Iwin Joseph, Utkarsh Bhore, Alex von Kriegsheim, Giulia Petrovich, Jocelyn Charlton, Viktoriya G. Stancheva, Debasis Mohapatra, Abdelkader Essafi, Kathy Pritchard‐Jones, Nicholas Dixon Hastie, Ruthrothaselvi Bharathavikru

The paper shows WT1 and DDX5 regulate the let7/Igf1r axis in kidney mesenchyme, linking WT1 mutations to Wilms Tumour through microRNA and IGF signalling pathways.

bioRxiv · Jan 5, 2025 · PreprintCancer Biology

Functionally Coherent Transcription Factor Target Networks Illuminate Control of Epithelial Remodelling

Ian M. Overton, Andrew H. Sims, Jeremy A. Owen, Bret S.E. Heale, Matthew J. Ford, Alexander L. R. Lubbock, Erola Pairo‐Castineira, Abdelkader Essafi

The paper introduces NetNC, a tool to identify functionally coherent TF targets, showing it effectively finds neutral binding and reveals new gene functions in EMT processes.

Cancers · Sep 30, 2020Peer-reviewedSystems Biology