Abdul I. Barakat

A nematic framework for sprouting angiogenesis

This study uses a nematic framework to show that endothelial cell orientation gradients drive angiogenic sprouting, with implications for therapeutic strategies.

Collagen-based bilayered biomimetic tubular materials for vascular and airway applications

This paper presents collagen-based bilayered tubular scaffolds for vascular and airway applications, demonstrating compliance and flexibility suitable for implants but with limitations in suture retention strength.

A Morphodynamic Network Model to Describe Cell Organization and Nematic Ordering in Monolayers

This paper introduces a new computational model to simulate cell monolayers and study nematic ordering and morphodynamic behaviors.

Adaptation of endothelial cells to microenvironment topographical cues through lysyl oxidase like-2-mediated basement membrane scaffolding

This study shows LOXL2 mediates BM assembly in response to microenvironment topography, affecting endothelial cell behavior and barrier properties.

A Variational Autoencoder Model for Clustering of Cell Nuclei on Microgroove Substrates: Potential for Disease Diagnosis

This study uses a variational autoencoder to cluster nuclei on microgroove substrates, distinguishing between wildtype and laminopathy myoblasts based on nuclear deformation.

Interplay of actin nematodynamics and anisotropic tension controls endothelial mechanics

The paper studies how actin dynamics and tension affect endothelial cell mechanics under pressure, showing strain-stiffening and actin-driven reorientation.

Microgroove substrates unveil topography-driven, dynamic 3D nuclear deformations

This study uses microgroove substrates to show that adherent cells exhibit dynamic 3D nuclear deformations driven by adhesion, with implications for diagnosing nuclear mechanical disorders.