TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer.
Laura Morano, Nadia Vié, Adam Aissanou, Tom Egger, Antoine Aze, Solène Fiachetti, Benoît Bordignon, Cédric Hassen‐Khodja, Hervé Seitz, Louis-Antoine Milazzo, Véronique Garambois, Laurent Chaloin, Nathalie Bonnefoy, Céline Gongora, Angelos Constantinou, Jihane Basbous
This study identifies TopBP1 condensation inhibitors, showing AZD2858 disrupts ATR signaling and synergizes with chemotherapy in colorectal cancer.
eLife · Oct 21, 2025Peer-reviewedCancer Biology