Amreen Mughal

Electro-Calcium uncoupling precedes neurodegeneration in Alzheimers disease

This study shows that electro-calcium uncoupling in endothelial cells precedes neurodegeneration and cognitive decline in 5xFAD mice.

Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature

The paper characterizes primary cilia and centriole organization in mouse and human brain microvasculature, revealing interspecies differences and their potential role in sensing microenvironmental signals.

Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature

This study shows that pathogenic tau peptides reduce endothelial calcium signaling and vasodilation in brain microvessels, impairing cerebral blood flow.

Electro-Metabolic Sensing Through Capillary ATP-Sensitive K+ Channels and Adenosine to Control Cerebral Blood Flow

The paper demonstrates that brain capillary endothelial cells and pericytes express functional KATP channels that regulate membrane potential and cerebral blood flow through adenosine signaling.

Brain Endothelial Cell TRPA1 Channels Initiate Neurovascular Coupling

The paper identifies TRPA1 channels in brain capillary endothelial cells as key initiators of neurovascular coupling by generating retrograde signals that dilate upstream arterioles.