Author

Advaiti Pai Kane

Duke UniversityPrimary ORCID profile (0000-0002-4715-0888 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Advaiti Pai KaneiD1 paper · Duke University

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Amanda NewmaniD· 1 shared Ankita Singh· 1 shared Barton F. HaynesiD· 1 shared Derek W. CainiD· 1 shared Elizabeth S. Van ItallieiD· 1 shared Frederick W. AltiD· 1 shared Kara M. AnastiiD· 1 shared Kevin J. WieheiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Amanda NewmanORCID

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1 paper

Recent·Most cited

B Cell Receptor Signaling Sets Boundaries for Selection of Broadly Neutralizing Antibody Functional Mutations

Ankita Singh, Kara M. Anasti, Elizabeth S. Van Itallie, Amanda Newman, Advaiti Pai Kane, Maggie Barr, Robert Parks, Sravani Venkatayogi, Ming Tian, Kevin O. Saunders, Rory C. Henderson, Derek W. Cain, Frederick W. Alt, Barton F. Haynes, Laurent K. Verkoczy, , S. Munir Alam

The paper shows that B cell receptor signaling sets limits on the selection of functional mutations in antibodies, with mid-affinity antigens showing optimal neutralization.

bioRxiv · Aug 19, 2026 · PreprintImmunology