B Cell Receptor Signaling Sets Boundaries for Selection of Broadly Neutralizing Antibody Functional Mutations
Ankita Singh, Kara M. Anasti, Elizabeth S. Van Itallie, Amanda Newman, Advaiti Pai Kane, Maggie Barr, Robert Parks, Sravani Venkatayogi, Ming Tian, Kevin O. Saunders, Rory C. Henderson, Derek W. Cain, Frederick W. Alt, Barton F. Haynes, Laurent K. Verkoczy, , S. Munir Alam
The paper shows that B cell receptor signaling sets limits on the selection of functional mutations in antibodies, with mid-affinity antigens showing optimal neutralization.
bioRxiv · Aug 19, 2026 · PreprintImmunology