S. Munir Alam

This study reports cryo-EM structures of full-length BCRs, revealing their dynamic conformation and antigen binding-induced signaling mechanisms.

The paper shows that B cell receptor signaling sets limits on the selection of functional mutations in antibodies, with mid-affinity antigens showing optimal neutralization.

This study identifies binding dynamics as a key factor in enhancing germinal center responses to HIV immunogens, improving the efficiency of somatic hypermutation and bnAb precursor activation.