Scarless SARS-CoV-2 Genome Engineering and Variant Analysis
Agnieszka Dabrowska, Ashley Cuell, Rahul Basu, Jyoti Vishwakarma, Renee Delgado, Emilia Barreto-Durán, Xingyu Liu, He Li, Yan Xiang, Chengjin Ye, Luis Martínez‐Sobrido, Reuben S. Harris
This paper develops a scarless genome engineering system for SARS-CoV-2 to study protease inhibitors and drug resistance mechanisms, showing improved antiviral potency when combined with drug efflux inhibitors.
bioRxiv · Aug 24, 2026 · PreprintMicrobiology