Jyoti Vishwakarma

A SARS-CoV-2 entry inhibitor trimerizes to lock the spike protein in a closed conformation

This paper describes a trimeric inhibitor, S22, that stabilizes the SARS-CoV-2 spike protein in a closed conformation, preventing ACE2 binding and viral entry.

Scarless SARS-CoV-2 Genome Engineering and Variant Analysis

This paper develops a scarless genome engineering system for SARS-CoV-2 to study protease inhibitors and drug resistance mechanisms, showing improved antiviral potency when combined with drug efflux inhibitors.

SARS-CoV-2 Omicron Envelope T9I adaptation confers resistance to autophagy

The paper shows that the T9I mutation in the SARS-CoV-2 E protein confers autophagy resistance in Omicron variants, contributing to their spread.