Emilia Barreto-Durán

Scarless SARS-CoV-2 Genome Engineering and Variant Analysis

This paper develops a scarless genome engineering system for SARS-CoV-2 to study protease inhibitors and drug resistance mechanisms, showing improved antiviral potency when combined with drug efflux inhibitors.

Mus Musculus papillomavirus MmuPV1 resists restriction by human APOBEC3B

This study shows human APOBEC3B does not restrict murine papillomavirus MmuPV1 replication in cellulo or in vivo, suggesting papillomaviruses have evolved mechanisms to evade this antiviral factor.

Structural basis for sequence context-independent single-stranded DNA cytosine deamination by the bacterial toxin SsdA

This study reports the crystal structure of SsdA, a bacterial ssDNA deaminase, revealing its unique substrate binding mechanism and sequence-independent activity.

Carcinogen-induced DNA adducts amplify APOBEC mutagenesis through nucleotide excision repair

This study shows that carcinogen-induced DNA adducts enhance APOBEC3B-mediated mutagenesis, leading to increased mutation rates in cancer genomes.