The nuclear actin cytoskeleton supports DNA double-strand break repair via VCP-mediated extraction of the KU70/80 complex from damaged chromatin
Kristine Hauschulte, Jie Debbie Shi, Ronald P.C. Wong, Felizitas F. Stiehler, Sebastian Richenhagen, Aisha A. Kahloon, Lea-Marie Vogts, Markus S Schraft, Tina Strauch, Stephanie Nick, Ivan Mikičić, Márton Gelléri, Fridolin Kielisch, Vassilis Roukos, Krishnaraj Rajalingam, , Hans-Peter Wollscheid
This study identifies Myo6's role in DSB repair by interacting with KU70/80 and VCP, facilitated by F-actin, to extract the KU70/80 complex from chromatin.
bioRxiv · Sep 2, 2026 · PreprintCell Biology