Vassilis Roukos

The nuclear actin cytoskeleton supports DNA double-strand break repair via VCP-mediated extraction of the KU70/80 complex from damaged chromatin

This study identifies Myo6's role in DSB repair by interacting with KU70/80 and VCP, facilitated by F-actin, to extract the KU70/80 complex from chromatin.

The phosphoproteomic landscape of the DNA damage response

This study profiles the human phosphoproteome in response to eleven DNA damage agents, identifying core phosphorylation sites and DDR signatures, and links proteasome regulation to the DDR via UBE3A.

RepliCNN: High-resolution inference of the DNA replication program from strand-specific 3' DNA end sequencing

RepliCNN predicts DNA replication timing and related features from strand-specific 3' DNA end sequencing data with high accuracy.

Coordinated control of genome-nuclear lamina interactions by Topoisomerase 2B and Lamin B receptor

The paper identifies TOP2B as a regulator of genome-nuclear lamina interactions, showing its role in partitioning genomic regions between the nuclear lamina and interior, with LBR playing a complementary role.

RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis

The paper shows RNA polymerase II is necessary for spatial chromatin reorganization after mitosis, as demonstrated by Hi-C and in silico modeling.

Spatially clustered loci with multiple enhancers are frequent targets of HIV-1

The paper identifies spatially clustered genes with multiple enhancers as frequent targets of HIV-1 integration in T cells.