Author

Dmitrii Glubokov

Brigham and Women's HospitalORCID 0000-0002-3443-6852Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2

Frequent Co-Authors

Alexander TyshkovskiyiD· 4 shared Vadim N. GladysheviD· 4 shared Jesse R. PoganikiD· 3 shared Kejun YingiD· 3 shared Mahdi MoqriiD· 3 shared Adrian MolièreiD· 2 shared Alibek MoldakozhayeviD· 2 shared Sharif IqbaliD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersSystems Biology

Alexander TyshkovskiyORCID

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4 papers

Recent·Most cited

Systemic control and inter-organ communication of ovarian aging

Sharif Iqbal, Alexander Tyshkovskiy, Bohan Zhang, Sirui Zhang, Adrian Molière, Kejun Ying, Yunhao Bai, Harlan Steven, Ludger Goeminne, Juan José Alba‐Linares, Erik Jacques, Md Amin Hossain, Dmitrii Glubokov, Alibek Moldakozhayev, Jesse R. Poganik, , Vadim N. Gladyshev

This study shows ovarian aging can shift in both directions depending on the systemic environment through inter-organ communication and molecular changes.

bioRxiv · Oct 13, 2026 · PreprintSystems Biology

Integrative epigenetics and transcriptomics identify aging genes in human blood

Mahdi Moqri, Kejun Ying, Jesse R. Poganik, Chiara Maria Stella Herzog, Qingwen Chen, Mehrnoosh Emamifar, Alexander Tyshkovskiy, Alec Eames, Jure Mur, Dmitrii Glubokov, Benyamin Matei-Dediu, Ludger J.E. Goeminne, Wayne Mitchell, Daniel L. McCartney, Lucas A. Salas, , Vadim N. Gladyshev

This study identifies aging genes in human blood by integrating epigenetic and transcriptomic data, finding genes enriched for immune functions that better replicate across populations and link to aging outcomes.

Nature Communications · Jan 19, 2026Peer-reviewedSystems Biology

Multi-tissue spatial transcriptomics reveals biological age hotspots in mouse and human aging

Victor Vicente-Alvarez, Cecilia G. de Magalhaes, Dmitrii Glubokov, Adrian Molière, Alexander Tyshkovskiy, Vadim N. Gladyshev

The paper introduces stAge, a framework to quantify localized transcriptomic age from spatial transcriptomics data, revealing spatial gradients and age acceleration in mouse and human aging.

bioRxiv · Nov 23, 2025 · PreprintBioinformatics

Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles

Kejun Ying, Alexander Tyshkovskiy, Alibek Moldakozhayev, Hanchen Wang, Cecília G. De Magalhães, Sharif Iqbal, Amanda E. Garza, Albina Tskhay, Jesse R. Poganik, Kexin Huang, Yuanhao Qu, Dmitrii Glubokov, Cheng Jin, Donghyun Lee, Hanna Liu, , Vadim N. Gladyshev

The paper reanalyzes millions of molecular profiles to identify aging interventions using AI agents, finding over 500 interventions that reduce biological age and revealing patterns in aging modulation.

bioRxiv · Feb 28, 2023 · PreprintBioinformatics