Author
Broad InstituteORCID 0000-0002-0366-2080Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Sharif Iqbal, Vadim N. Gladyshev
This study shows that tissue regeneration in mice reduces transcriptomic age temporarily, with variations depending on tissue type and repair stage.
bioRxiv · Oct 26, 2026 · PreprintCell Biology
Sharif Iqbal, Alexander Tyshkovskiy, Bohan Zhang, Sirui Zhang, Adrian Molière, Kejun Ying, Yunhao Bai, Harlan Steven, Ludger Goeminne, Juan José Alba‐Linares, Erik Jacques, Md Amin Hossain, Dmitrii Glubokov, Alibek Moldakozhayev, Jesse R. Poganik, , Vadim N. Gladyshev
This study shows ovarian aging can shift in both directions depending on the systemic environment through inter-organ communication and molecular changes.
bioRxiv · Oct 13, 2026 · PreprintSystems Biology
Alibek Moldakozhayev, Alexander Tyshkovskiy, Pasquale Nigro, Zehao Zhang, Albina Tskhay, Cecília Gallottini de Magalhães, Shweta Yadav, Kejun Ying, Alec Eames, Jesse R. Poganik, Shakchhi Joshi, Ji Seul Han, Daria Kholdina, Wayne Mitchell, João A. Paulo, , Vadim N. Gladyshev
This study shows that old white adipose tissue can rejuvenate in young hosts through thermogenic remodeling and pathway activation, reversing biological age markers.
bioRxiv · Sep 30, 2026 · PreprintSystems Biology
Sirui Zhang, Sharif Iqbal, Alexander Tyshkovskiy, Vadim N. Gladyshev
This paper introduces a computational framework to quantify transcriptomic damage across tissues and conditions, revealing age-associated increases and demonstrating that interventions can alter tDamAge.
bioRxiv · Jun 29, 2026 · PreprintBioinformatics
Ashish A. Kumar, Sharif Iqbal, Ernesta Nestaite, Nalle Pentinmikko, Martin E. Broberg, Jack Morikka, Ville Hietakangas, Pekka Katajisto
This study shows that Paneth cells use alanine catabolism to produce lactate, which supports intestinal stem cell function during dietary restriction.
bioRxiv · Aug 28, 2025 · PreprintCell Biology
Sharif Iqbal, Simon Andersson, Ernesta Nesta, Nalle Pentinmikko, Ashish A. Kumar, Sawan Kumar Jha, Daniel Borshagovski, Anna Webb, Nadja Gebert, Emma W Viitala, Alexandra Ritchie, Sandra Scharaw, Emilia Kuuluvainen, Hjalte List Larsen, Tuure Saarinen, , Pekka Katajisto
The paper shows that mesenchymal Asporin mediates fetal-like reprogramming in regenerating intestinal epithelium by modulating Tgfβ signaling through CD44.
Cell stem cell · Mar 6, 2025Peer-reviewedDevelopmental Biology
Kejun Ying, Alexander Tyshkovskiy, Alibek Moldakozhayev, Hanchen Wang, Cecília G. De Magalhães, Sharif Iqbal, Amanda E. Garza, Albina Tskhay, Jesse R. Poganik, Kexin Huang, Yuanhao Qu, Dmitrii Glubokov, Cheng Jin, Donghyun Lee, Hanna Liu, , Vadim N. Gladyshev
The paper reanalyzes millions of molecular profiles to identify aging interventions using AI agents, finding over 500 interventions that reduce biological age and revealing patterns in aging modulation.
bioRxiv · Feb 28, 2023 · PreprintBioinformatics
Joel Johnson George, Mikko Oittinen, Laura Martín-Díaz, Veronika Zapilko, Sharif Iqbal, Terhi Rintakangas, Fábio Tadeu Arrojo Martins, Henri Niskanen, Pekka Katajisto, Minna Unelma Kaikkonen, Keijo M. Viiri
The paper identifies Essrg as a necessary factor for Sox8-mediated M cell differentiation, regulated by PRC2 during intestinal M cell development.
bioRxiv · Nov 13, 2020 · PreprintMolecular Biology