Zehao Zhang

This study shows that old white adipose tissue can rejuvenate in young hosts through thermogenic remodeling and pathway activation, reversing biological age markers.

This study constructs a single-cell chromatin accessibility atlas across mouse tissues to reveal age-related cellular and epigenomic changes, showing widespread population shifts and sex-dependent dynamics.

This study uses single-nucleus genomics and spatial transcriptomics to show that caloric restriction modulates aging-related changes in mouse brains, reducing inflammation and stress pathways while restoring circadian and cognitive genes.

EnrichSci enables targeted profiling of specific cell types in complex tissues, revealing aging-associated molecular dynamics and post-transcriptional regulation.

PanSci, a single-cell transcriptome atlas of over 20 million cells throughout the mouse lifespan, unveils the temporal architecture of aging-associated cellular population dynamics, organ-specific immune cell shifts, and the lymphocytes role in organismal aging.

IRISeq, an optics-free spatial transcriptomics method, uncovers aging-related changes in spatial gene expression and focal cell interactions in brain aging.

The paper develops a high-throughput single-cell genomics approach to study age-related and Alzheimer's disease-associated cell population dynamics and molecular signatures in human and mouse brains.