Enhancer-promoter interactions are reconfigured through the formation of long-range multiway chromatin hubs as mouse ES cells exit pluripotency
David Lando, Xiaoyan Ma, Yang Cao, Aleksandra Jartseva, Tim J. Stevens, Wayne Boucher, Nicola Reynolds, Bertille Montibus, Dominic Hall, Andreas Lackner, Ramy Ragheb, Martin Leeb, Brian Hendrich, Ernest D. Laue
The paper studies 3D genome structure changes in single mouse ES cells exiting pluripotency, finding reorganization of enhancer-promoter interactions through multiway chromatin hubs.
Molecular Cell · Mar 14, 2024Peer-reviewedDevelopmental Biology