Tim J. Stevens

Integration of SYT1 Interactomics and Dual-Localization Proteomics Links ER-PM Contacts to Lignin Deposition

The paper integrates proteomic and interactomic data to identify SYT1-associated proteins at ER-PM contact sites and links them to lignin deposition.

Choragraph: A deep-learning approach for the analysis of spatial proteomics reveals subcellular Arabidopsis protein trafficking routes and multi-residency

Choragraph uses deep learning to analyze spatial proteomics data, reconstructing missing values and identifying subcellular localization, including dual-residency in Arabidopsis.

Identification of Cellular Signatures Associated with Chinese Hamster Ovary (CHO) Cell Adaptation for Secretion of Antibodies

This study identifies cellular adaptations in CHO cells linked to antibody production, finding that transgene copy number and mRNA expression levels are key factors in productivity.

Enhancer-promoter interactions are reconfigured through the formation of long-range multiway chromatin hubs as mouse ES cells exit pluripotency

The paper studies 3D genome structure changes in single mouse ES cells exiting pluripotency, finding reorganization of enhancer-promoter interactions through multiway chromatin hubs.

Zasp52 strengthens whole embryo tissue integrity through supracellular actomyosin networks

The paper shows Zasp52, a Drosophila protein, is part of supracellular actomyosin networks that maintain tissue integrity during embryogenesis by insulating morphogenetic changes.

Functional unknomics: closing the knowledge gap to accelerate biomedical research

The paper develops an 'Unknome database' to prioritize understudied proteins and validates their functions using Drosophila RNAi and CRISPR/Cas9.

Rho-kinase planar polarisation at tissue boundaries depends on phospho-regulation of membrane residence time

The paper shows that Rho-kinase membrane residence time is regulated by phospho-modulation at tissue boundaries, affecting planar polarization during morphogenesis.

Triparental inheritance in Dictyostelium

The paper studies meiotic recombination in Dictyostelium discoideum, finding high-frequency recombination and triparental inheritance despite the absence of SPO11.