Author

Yvette A. Luyten

New England Biolabs (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:database / resource· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1

Frequent Co-Authors

Barry L. StoddardiD· 2 shared Brett K. KaiseriD· 2 shared Lindsey DoyleiD· 2 shared Richard J. RobertsiD· 2 shared Richard MorganiD· 2 shared Abigail KellyiD· 1 shared Abigail R. Lambert· 1 shared Alex J Kaiser· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

Barry L. StoddardORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A virion protein of an archaeal virus inhibits a Type V BREX defense system in Haloarcula hispanica

Julia Gordeeva, Richard Morgan, Ananya Jain, Alexey I. Fomenkov, Yvette A. Luyten, Tamas Vincze, Richard J. Roberts, Alfred A. Antson, Konstantin Severinov

This study characterizes a Type V BREX defense system in Haloarcula hispanica and shows that two archaeal viruses evade it via a virion protein.

bioRxiv · Apr 29, 2026 · PreprintMolecular Biology

Competing forms of protein-protein association and DNA binding exhibited by BrxC from the BREX phage restriction system

Alex J Kaiser, Jennifer J. Readshaw, Lindsey Doyle, Maria Puiu, Abigail Kelly, Sydney F. McGuire, Julieta Peralta Acosta, Duc Vu, Andrew Nelson, Darren L. Smith, Lidia Araújo‐Bazán, Ernesto Arias‐Palomo, Yvette A. Luyten, Barry L. Stoddard, Tim R. Blower, Brett K. Kaiser

This study investigates the structural and functional properties of BrxC, a conserved AAA+ ATPase in the BREX phage restriction system, revealing its role in mediating competing protein associations and DNA binding that regulate host methylation and phage restriction.

bioRxiv · Apr 11, 2026 · PreprintBiochemistry

Proxi-RIMS-seq2 applied to native microbiomes uncovers hundreds of known and novel m5C methyltransferase specificities.

Weiwei Yang, Yvette A. Luyten, Emily Reister, Hayley Mangelson, Zach Sisson, Benjamin Auch, Ivan Liachko, Richard J. Roberts, Laurence M. Ettwiller

The paper applies Proxi-RIMS-seq2 to native microbiomes to identify m5C methylation motifs and their cognate methyltransferases, revealing over 1900 motifs including a novel 8-base recognition site.

Nucleic Acids Research · Mar 20, 2025Peer-reviewedGenomics

Identification and characterization of the WYL BrxR protein and its gene asseparable regulatory elements of a BREX phage restriction system

Yvette A. Luyten, Deanna Hausman, Juliana C. Young, Lindsey Doyle, Kerilyn M. Higashi, Natalia C. Ubilla‐Rodriguez, Abigail R. Lambert, Corina S. Arroyo, Kevin J. Forsberg, Richard Morgan, Barry L. Stoddard, Brett K. Kaiser

The paper identifies and characterizes the BrxR protein and its gene in a BREX phage restriction system from Acinetobacter, showing its role in restriction and cis regulation.

Nucleic Acids Research · Apr 19, 2022Peer-reviewedMolecular Biology