Author

Isaac Kraz

Albert Einstein College of MedicineORCID 0000-0001-8454-1426Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

David ShechteriD· 2 shared Sarah GraffiD· 2 shared Simone SidoliiD· 2 shared Adam G. ChatoffiD· 1 shared Alex J. Poppel· 1 shared Benjamin M. LortoniD· 1 shared Daniel GroomiD· 1 shared Derek M. HuffmaniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

David ShechterORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJun 1, 2026

Histone succinylation directly inhibits Jumonji domain demethylases and stabilizes repressive chromatin states

Sarah Graff, Stephanie Stransky, Isaac Kraz…·Simone Sidoli

This study identifies histone succinylation as an inhibitor of JmjC demethylases, leading to stabilized repressive chromatin states and reduced transcription.

DOI 10.64898/2026.05.29.728167

humanChIP-seq

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BiochemistrybioRxivPreprintMay 29, 2026

The GNMT N-terminus Couples Folate Feedback to Methyl-donor Homeostasis

Isaac Kraz, Oi Wei Mak, Subray Hegde…·David Shechter

This study identifies the GNMT N-terminal tail and its phosphorylation at S9 as a regulatory mechanism linking folate feedback to SAM homeostasis.

DOI 10.64898/2026.05.26.727678

mouseproteomics

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