Jerome Irianto

Rotational migration in human pancreatic ductal organoids depends on actin and myosin activity

This study investigates rotational migration in human pancreatic ductal organoids, showing it depends on actin and myosin activity through inhibition experiments.

Traction force dynamics during patient-derived glioblastoma neurosphere invasion in 3D Matrigel

This study quantifies the mechanical dynamics of GBM neurosphere invasion in 3D Matrigel, identifying key roles for actomyosin contractility and microtubules in invasion.

SCsnvcna: Integrating SNVs and CNAs on a phylogenetic tree from single-cell DNA sequencing data

SCsnvcna places SNVs on a CNA tree using independent cell sets, improving accuracy in predicting SNV placement and losses due to copy number changes.

Heterogeneous strains in tissue collagen show that high strains locally suppress degradation by collagenase

This paper investigates how mechanical strain affects collagen degradation in tendon and heart tissues, finding that moderate strains suppress degradation while higher strains do not.

Live cell monitoring for factors affecting genome variation

The paper monitors live cell fluorescence to quantify aneuploidy-inducing perturbations in lung cancer and iPS cells, revealing increased chromosome mis-segregation and rare fluorescent-null cells.

Cell cycle repression and DNA repair defects follow constricted migration

The paper shows that constricted migration causes nuclear rupture and DNA damage, which are linked to cell cycle repression and DNA repair defects in cancer cells.

DNA damage in 3D constricted migration or after lamin-A depletion in 2D: shared mechanisms of repair factor mis-localization under nuclear stress

Constricted cell migration causes nuclear lamina damage, DNA breaks, and squeeze-out of repair factors

The paper shows that constricted cell migration in stiff tissues causes nuclear lamina damage, DNA breaks, and loss of repair factors, leading to genomic instability.