Manasvita Vashisth

Gene expression inference from cell-free DNA using uncertainty-aware deep learning

This paper develops a deep learning framework to infer gene expression from cell-free DNA, improving reliability and enabling functional genomics in precision oncology.

RCC1 depletion drives protein transport defects and rupture in micronuclei

This study identifies RCC1 depletion as a cause of protein transport defects and micronuclei rupture, linking it to nuclear lamina defects and genome instability.

Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies

This study shows that acute CDK12 loss in prostate cancer causes HR deficiency via polyadenylation, but chronic loss leads to adaptation, making PARP inhibitors ineffective and suggesting CDK13 targeting as a new therapeutic approach.

Heterogeneous strains in tissue collagen show that high strains locally suppress degradation by collagenase

This paper investigates how mechanical strain affects collagen degradation in tendon and heart tissues, finding that moderate strains suppress degradation while higher strains do not.