Author

Alex Shida

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:protein design· 2 Assay:protein structure· 2 Approach:diffusion model· 1 Approach:experimental assay· 1 Assay:protein sequence· 1

Frequent Co-Authors

David A. BakeriD· 3 shared Alex KangiD· 2 shared Asim K. BeraiD· 2 shared Samuel J. PellockiD· 2 shared Adam J. BroermaniD· 1 shared Ana María Fernández‐EscamillaiD· 1 shared Andrew C. HuntiD· 1 shared Anna LaukoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

David A. BakerORCID

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Author profile →

3 papers

Recent·Most cited

De novo design of allosterically controlled enzymes

Alex Shida, Kelly Wang, Hojae Choi, Samuel J. Pellock, Adam J. Broerman, Saman Salike, William S. Grubbe, Emily Joyce, Alex Kang, Asim K. Bera, Xinting Li, Arvind S. Pillai, David A. Baker

This study designs allosterically controlled enzymes using denoising diffusion models, showing that activity can be activated or repressed by designed effectors.

bioRxiv · Sep 10, 2026 · PreprintBiochemistry

De novo design of selective kinase modulators

Magnus S. Bauer, Saurav Kumar, Mia S. Donald-Paladino, Dongyang Li, Kody A. Klupt, Matthias Glögl, Ana María Fernández‐Escamilla, Thomas Schlichthaerle, Edin Muratspahić, Xinru Wang, Ludwig Schmiderer, Sebastian Kenny, Brian Coventry, Bulat Faezov, Wei Chen, , David A. Baker

This study designs genetically encoded miniproteins to modulate FAK kinase activity, showing they can inhibit or activate FAK in vitro and in cells, and adapt them to target other kinases.

bioRxiv · Jul 13, 2026 · PreprintBiochemistry

Computational design of serine hydrolases

Anna Lauko, Samuel J. Pellock, Kiera H. Sumida, Ivan V. Anishchenko, David Juergens, Woody Ahern, Jihun Jeung, Alex Shida, Andrew C. Hunt, Indrek Kalvet, Christoffer Norn, Ian R. Humphreys, Cooper Stergis Jamieson, Rohith Krishna, Yakov Kipnis, , David A. Baker

This study designs novel serine hydrolases with high catalytic efficiency using computational methods, achieving structures close to design models and distinct from natural enzymes.

Science · Feb 13, 2025Peer-reviewedBiochemistry