Dongyang Li

This study designs genetically encoded miniproteins to modulate FAK kinase activity, showing they can inhibit or activate FAK in vitro and in cells, and adapt them to target other kinases.

The paper introduces DIMMERs, miRNA-based circuits that enable precise, tunable control of transgene expression across cell types, improving gene therapy and research applications.

The paper introduces a new image analysis pipeline for mother machine data and evaluates its performance against existing tools, highlighting parameter sensitivity and segmentation biases.

The paper evaluates five models of cell-cycle and cell-size control in bacteria, finding the Independent Double Adder model most consistent with experimental data.

The paper challenges the RDA model by showing it cannot compare biological models and is incompatible with the adder principle, supporting the IDA model instead.

The paper reanalyzes Witz et al.'s data and performs additional experiments, supporting the division-centric model of cell-size control in E. coli.

MM3 is a modular image analysis pipeline for mother machine experiments that converts raw images into cell feature data within a day.

The paper shows that cell size in Escherichia coli can be predicted by three biosynthesis variables and reveals the invariance of initiation mass under various perturbations.