Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer's disease
Sarah R. Ocañas, Kevin D. Pham, Jillian E. J. Cox, Alex W. Keck, Sung-Hwan Ko, Felix Agyei Ampadu, Hunter L. Porter, Victor A. Ansere, Adam M. Kulpa, Collyn M. Kellogg, Adeline H. Machalinski, Manu A. Thomas, Zsabre Wright, Ana J. Chucair‐Elliott, Willard M. Freeman
The paper identifies sex differences in microglial transcriptomic and translatomic profiles in aging mouse hippocampus, highlighting female-biased senescence and disease-associated signatures linked to Alzheimer's disease.
Journal of Neuroinflammation · Aug 16, 2023Peer-reviewedNeuroscience