Collyn M. Kellogg

A new epigenetic framework for DNA methylation, hydroxymethylation, and gene expression during brain aging.

The paper shows that cell identity and regulatory logic are preserved during brain aging, but cell-type-specific changes occur in DNA modifications and gene expression.

Consistent specificity and efficiency of tamoxifen-mediated cre induction across ages

The paper compares tamoxifen-mediated cre induction efficiency and specificity in young and old mice, finding no significant difference in microglial labeling or translatomic changes.

Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer's disease

The paper identifies sex differences in microglial transcriptomic and translatomic profiles in aging mouse hippocampus, highlighting female-biased senescence and disease-associated signatures linked to Alzheimer's disease.

Microglial MHC-I induction with aging and Alzheimer's is conserved in mouse models and humans

The paper identifies microglia as the primary source of MHC-I in mice and humans, showing age-related and Alzheimer's-associated increases in MHC-I expression and related receptors.