Author

Adam M. Kulpa

Oklahoma Medical Research FoundationORCID 0009-0003-4177-3114Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:mouse· 3 Assay:DNA methylation· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Adeline H. Machalinski· 3 shared Ana J. Chucair‐ElliottiD· 3 shared Kevin D. Pham· 3 shared Sarah R. OcañasiD· 3 shared Willard M. FreemaniD· 3 shared Collyn M. KelloggiD· 2 shared David R. StanfordiD· 2 shared Victor A. AnsereiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersNeuroscience

Adeline H. Machalinski

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 21, 2026

A new epigenetic framework for DNA methylation, hydroxymethylation, and gene expression during brain aging.

Sarah R. Ocañas, Walker Hoolehan, Kevin D. Pham…·Willard M. Freeman

The paper shows that cell identity and regulatory logic are preserved during brain aging, but cell-type-specific changes occur in DNA modifications and gene expression.

DOI 10.64898/2026.10.15.757659

mouseDNA methylation

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GenomicsEpigenetics & ChromatinPeer-reviewedNov 12, 2023

Differential usage of DNA modifications in neurons, astrocytes, and microglia

Kyla B. Tooley, Ana J. Chucair‐Elliott, Sarah R. Ocañas…·Willard M. Freeman

The paper identifies differential DNA modifications across CNS cell types and their relationship with gene expression using a novel mouse model and epigenomic sequencing.

15 citations

mouseDNA methylation

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NeuroscienceJournal of NeuroinflammationPeer-reviewedAug 16, 2023

Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer's disease

Sarah R. Ocañas, Kevin D. Pham, Jillian E. J. Cox…·Willard M. Freeman

The paper identifies sex differences in microglial transcriptomic and translatomic profiles in aging mouse hippocampus, highlighting female-biased senescence and disease-associated signatures linked to Alzheimer's disease.

82 citationstop 1%

mousebulk RNA-seq

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