Victor A. Ansere

A new epigenetic framework for DNA methylation, hydroxymethylation, and gene expression during brain aging.

The paper shows that cell identity and regulatory logic are preserved during brain aging, but cell-type-specific changes occur in DNA modifications and gene expression.

Methylation Array Signals are Predictive of Chronological Age Without Bisulfite Conversion

The paper shows that non-methylation factors cause age-predictive pseudomethylation signals in methylation arrays, affecting epigenetic clocks.

Changes in microglia chromatin accessibility in aged female mice.

This study identifies age-related changes in chromatin accessibility in female microglia, showing more gains than losses in accessibility, enriched in immune-related genes and intergenic regions.

Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer's disease

The paper identifies sex differences in microglial transcriptomic and translatomic profiles in aging mouse hippocampus, highlighting female-biased senescence and disease-associated signatures linked to Alzheimer's disease.

Differential regulation of mouse hippocampal gene expression sex differences by chromosomal content and gonadal sex

The paper investigates how chromosomal content and gonadal sex influence gene expression and DNA modification patterns in mouse hippocampi, revealing sex chromosome-specific regulatory effects.

Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia

The paper introduces a NuTRAP method to isolate RNA and DNA from specific CNS cell types, revealing cell type-specific epigenetic and transcriptomic differences in microglia and astrocytes.