Author
Oklahoma Medical Research FoundationORCID 0000-0002-2495-2423Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Hunter L. Porter, Victor A. Ansere, Ram Babu Undi…·Jonathan D. Wren
The paper shows that non-methylation factors cause age-predictive pseudomethylation signals in methylation arrays, affecting epigenetic clocks.
Sarah R. Ocañas, Kevin D. Pham, Jillian E. J. Cox…·Willard M. Freeman
The paper identifies sex differences in microglial transcriptomic and translatomic profiles in aging mouse hippocampus, highlighting female-biased senescence and disease-associated signatures linked to Alzheimer's disease.
Collyn M. Kellogg, Kevin D. Pham, Adeline H. Machalinski…·Willard M. Freeman
The paper identifies microglia as the primary source of MHC-I in mice and humans, showing age-related and Alzheimer's-associated increases in MHC-I expression and related receptors.
Ana J. Chucair‐Elliott, Sarah R. Ocañas, David R. Stanford…·Willard M. Freeman
The paper introduces a NuTRAP method to isolate RNA and DNA from specific CNS cell types, revealing cell type-specific epigenetic and transcriptomic differences in microglia and astrocytes.
Dustin R. Masser, Niran Hadad, Hunter L. Porter…·Willard M. Freeman
This study identifies sexually divergent DNA methylation changes in mouse and human hippocampus with aging, revealing sex as a key factor in epigenomic aging.