Identifying Modulators of the Post-Antibiotic Effect
Alexa L. Gilberti, Megan M. Tu, Kenneth Rachwalski, Madeeha I. Ali, Siobhan A. Cohen, Melike Akoglu, Alyssa C. Pollard, Jinnette Tolentino Collado, Aya Sabbah, Franchesca Abou Said, Purnima Dela, Stephen G. Walker, John D. Haley, Eric D. Brown, Peter J. Tonge
This paper identifies genes that enhance the post-antibiotic effect (PAE) in E. coli using a high-throughput screen of deletion strains, revealing that rfaE deletion increases PAE by stabilizing LpxC.
ACS Infectious Diseases · Aug 6, 2025Peer-reviewedMicrobiology