Eric D. Brown

The paper identifies butyrolactol A as a compound that enhances caspofungin efficacy against resistant fungi by inhibiting phospholipid flippase, thereby improving antifungal treatment.

The paper identifies a conserved Streptomyces biosynthetic megacluster producing biotin-targeting antibiotics, effective against multidrug-resistant E. coli.

This paper identifies genes that enhance the post-antibiotic effect (PAE) in E. coli using a high-throughput screen of deletion strains, revealing that rfaE deletion increases PAE by stabilizing LpxC.

SyntheMol-RL generates novel and synthesizable antibiotics by optimizing for antibacterial activity and solubility, outperforming prior models and showing in vitro and in vivo efficacy.

This paper introduces micro-plaque assays to improve phage isolation and characterization, showing they can isolate 21 unique phages from one sample and identify phage susceptibility in clinical strains.

The paper constructs a mobile CRISPRi library in E. coli to study genetic interactions of essential genes by knocking down their expression and analyzing combined effects with non-essential gene deletions.