Irune Guerra San Juan

This study investigates the role of KIF5A in axonal transport and repair in human motor neurons, finding that its loss impairs mitochondrial and SFPQ granule transport and axonal regeneration.

This study combines Ngn2 overexpression with small molecule patterning to efficiently generate lower induced Motor Neurons (liMoNes) from hPSCs, achieving high yields and functional characteristics.

This study shows that TBK1 deficiency in human motor neurons causes TDP-43 proteinopathy through lysosomal dysfunction, and restoring TBK1 rescues the pathology.