Author

Laura Bortolin

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:scRNA-seq· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

Melissa GoldmaniD· 3 shared Steven A. McCarrolliD· 3 shared Alec Wysoker· 2 shared Arpiar B. SaundersiD· 2 shared David KulpiD· 2 shared Elizabeth BieniD· 2 shared Fenna M. KrieneniD· 2 shared James C. Nemesh· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersNeuroscience

Melissa GoldmanORCID

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Author profile →

3 papers

Recent·Most cited

Single-nucleus sequencing reveals enriched expression of genetic risk factors in Extratelencephalic Neurons sensitive to degeneration in ALS

Francesco Limone, Daniel A. Mordes, Alexander Couto, Brian J. Joseph, Jana M. Mitchell, Martine Therrien, Sulagna Dia Ghosh, Daniel Meyer, Yingying Zhang, Melissa Goldman, Laura Bortolin, Inma Cobos, Beth Stevens, Steven A. McCarroll, Irena Kadiu, , Kevin C. Eggan

The paper identifies cell type-specific molecular changes in ALS patients, showing enrichment of genetic risk factors in extratelencephalic neurons and altered responses in oligodendrocytes and microglia.

Nature Aging · Jun 21, 2024Peer-reviewedNeuroscience

Innovations in Primate Interneuron Repertoire

Fenna M. Krienen, Melissa Goldman, Qiangge Zhang, Ricardo C.H. del Rosario, Marta Florio, Robert P. Machold, Arpiar B. Saunders, Kirsten M. Levandowski, Heather Zaniewski, Benjamin Schuman, Carolyn W.‐H. Wu, Alyssa Lutservitz, Christopher D. Mullally, Nora M. Reed, Elizabeth Bien, , Steven A. McCarroll

The paper profiles interneurons in primates and rodents to identify evolutionary innovations in brain cell types and their molecular features.

Nature · Sep 30, 2020Peer-reviewedNeuroscience

A Single-Cell Atlas of Cell Types, States, and Other Transcriptional Patterns from Nine Regions of the Adult Mouse Brain

Arpiar B. Saunders, Evan Z. Macosko, Alec Wysoker, Melissa Goldman, Fenna M. Krienen, Heather de Rivera, Elizabeth Bien, Matthew L. Baum, Laura Bortolin, Shuyu Wang, Aleksandrina Goeva, James C. Nemesh, Nolan Kamitaki, Sara A. Brumbaugh, David Kulp, Steven A. McCarroll

This paper constructs a single-cell atlas of the adult mouse brain, identifying 565 transcriptionally distinct cell groups and revealing new insights into neuronal specialization and brain organization.

Cell · Aug 1, 2018Peer-reviewedNeuroscience