Human brain organoids record the passage of time over multiple years in culture
Irene Faravelli, Noelia Antón-Bolaños, Anqi Wei, Tyler Faits, Abhishek Sampath Kumar, Sophia Andreadis, Rahel Kästli, Marta Montero Crespo, Mara Steiger, Daniel Leible, Elizabeth Zhang, Bobae An, Yaron Meirovitch, Sayara Silwal, Sung Min Yang, , Paola Arlotta
This study shows human brain organoids can mature over 5 years in culture, transcriptionally aging and retaining memory of time spent in vitro.
bioRxiv · Oct 1, 2025 · PreprintNeuroscience