Tyler Faits

Human brain organoids record the passage of time over multiple years in culture

This study shows human brain organoids can mature over 5 years in culture, transcriptionally aging and retaining memory of time spent in vitro.

Fetal brain response to maternal inflammation requires microglia

This study shows that microglia mediate fetal brain transcriptional responses to maternal inflammation, highlighting their role in neurodevelopmental outcomes.

Multi-donor human cortical Chimeroids reveal individual susceptibility to neurotoxic triggers

The paper introduces a multi-donor brain organoid model called Chimeroids to study individual genetic variation in neurotoxin susceptibility.

Metagenomic profiling pipelines improve taxonomic classification for 16S amplicon sequencing data

The paper evaluates taxonomic classification accuracy of 16S amplicon sequencing data using different pipelines and reference databases, finding that whole-genome tools outperform 16S-specific ones.

Single-cell multiomics atlas of organoid development uncovers longitudinal molecular programs of cellular diversification of the human cerebral cortex

The paper presents a single-cell multiomics atlas of human cortical organoid development, revealing molecular programs of cellular diversification and identifying human-specific gene roles in lineage establishment.

Interactive single cell RNA-Seq analysis with the Single Cell Toolkit (SCTK)

The paper introduces SCTK, an interactive scRNA-Seq analysis tool with command-line and GUI interfaces for handling complex single-cell data.