Yaron Meirovitch

RAEM: random-access electron microscopy for revisitable 3D imaging

RAEM enables targeted, multi-resolution imaging of biological specimens by combining low-resolution 3D surveys with high-resolution imaging of specific regions.

SmartEM: machine-learning guided electron microscopy

SmartEM accelerates electron microscopy image acquisition by using machine learning to intelligently allocate imaging time, achieving up to 7-fold speedup in connectomic samples.

Human brain organoids record the passage of time over multiple years in culture

This study shows human brain organoids can mature over 5 years in culture, transcriptionally aging and retaining memory of time spent in vitro.

Developmental Connectomics of the Mouse Cerebellum

This study investigates synaptic connectivity development in the mouse cerebellum, revealing sequential input-dependent wiring and individualized parallel fiber inputs to Purkinje cells.

Cellular and synaptic organization of the Octopus vertical lobe

This paper examines the cellular and synaptic organization of the octopus vertical lobe, identifying unique structural and functional features compared to other associative networks.

EM-Compressor: Electron Microscopy Image Compression in Connectomics with Variational Autoencoders

EM-Compressor uses Variational Autoencoders to compress EM images for connectomics, reducing data size to 1/128th while preserving features needed for segmentation.

Mapping Alzheimer Disease Molecular Pathologies in Large-Scale Connectomics Data: A Publicly Accessible Correlative Microscopy Resource

The paper presents a vCLEM protocol to map Aβ and pTau in AD mouse hippocampus connectomics data, revealing new molecular and structural alterations.

A Scalable Staining Strategy for Whole-Brain Connectomics

The paper introduces a 12-step protocol called ODeCO to infiltrate osmium in whole mouse brains, preserving ultrastructure for connectome mapping.

mEMbrain: an interactive deep learning MATLAB tool for connectomic segmentation on commodity desktops

mEMbrain provides an interactive MATLAB tool for connectomic segmentation, enabling user-friendly analysis of EM datasets with pre-trained networks and ground truth annotations.

Connectomics of the Octopus vulgaris vertical lobe provides insight into conserved and novel principles of a memory acquisition network

The paper analyzes the connectome of the Octopus vulgaris vertical lobe, identifying novel synaptic structures and functional roles in memory acquisition.

Multiplexed volumetric CLEM enabled by antibody derivatives provides new insights into the cytology of the mouse cerebellar cortex

The paper introduces a vCLEM method using fluorescent scFvs to combine molecular labeling with ssEM, revealing new cell types and subcellular features in mouse cerebellar cortex.

Neuromuscular connectomes across development reveal synaptic ordering rules

The paper traces neuromuscular connectivity in mice across development, revealing that synaptic pruning follows a global activity-based ordering rule.

Connectomes across development reveal principles of brain maturation

This study uses connectomics to show how brain circuits change with age in C. elegans, revealing principles of brain maturation through structural and functional remodeling.